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Home 2019

Synthesis of 1,2,3-triazole derivative at 3rd position of coumarin via copper(I) catalyzed click chemistry using ternary solvent system (DMF + t-BuOH + water)

Authors: Shahrukhkhan Safi, Ashish Dhamsaniya, Wilson Christian, Prachi Trivedi, Pratiksha Chhatbar, Anamik Shah, 128(2) (2019) 255-301

2024-01-26
Reading Time: 2 mins read
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ABSTRACT

Coumarin-based triazoles were synthesized from 2-azido-N-phenylacetamide and terminal acetylenic compound by click chemistry. Whereas the CuSO4 used catalyts and sodium ascorbate used as a reducant affords only the favourable 1,4-regioisomer of triazole. Here DMF + t-BuOH + water used as a solvent.

 

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Tags: Click ChemistryCoumarinheterocyclic hybridstriazole
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