Schiff base was obtained from the reaction between 2-amino benzohydrazide and 2-Hydroxy-4-methoxy benzaldehyde using the reflux method in HPLC grade methanol for 2 hours producing 71% yield. 2-amino benzohydrazide 2-Hydroxy-4-methoxy benzaldehyde schiff base was slight yellow color. The structures characterized by ESI-mass, Mass, 1H NMR, IR, 13C NMR, the metal complex of quinazolinone schiff base derivative were tested for antibiotics such as Streptomycin, Ampicillin and Nystatin. Metal complexes of Ni, Zn, Cu, and Pd were prepared in which Ni metal complex and Pd metal complex are highly potent drug that inhibit only gram-negative bacteria. All the metal complexes are able to inhibit gram negative bacteria. Zn and Cu metal complexes are effective broad-spectrum drug which can inhibit the growth of both gram-positive and gram-negative bacteria. All the metal complexes exhibited antifungal activity. Among them, Pd metal complex is most potent antifungal drug.
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