**ABSTRACT**

A series of heterocyclic Schiff base compounds have been synthesized from 4H-1,2,4-triazol-4-

amine with various substituted benzaldehydes and were refluxed for 3h with 20 mL of absolute

ethanol. The purity of all the Schiff base compounds has been checked using their physical constants

and spectral data. The UV λmax (nm), IR νC=N (cm-1), NMR δ (ppm) of CH=N and C=N spectral data

have been correlated with Hammett substituent constants and Swain-Lupton’s parameters using single

and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents

on the above spectral data has been studied. The single parameter correlation with few Hammett

constants and Swain-Lupton’s parameters gave satisfactory correlation coefficients whereas all

multiple correlations gave satisfactory correlation coefficients with Inductive, Resonance, Field and

Swain-Lupton’s parameters. The antimicrobial activities of all the Schiff bases have been studied

using standard methods.

**References**

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