ABSTRACT
A series of heterocyclic Schiff base compounds have been synthesized from 4H-1,2,4-triazol-4-
amine with various substituted benzaldehydes and were refluxed for 3h with 20 mL of absolute
ethanol. The purity of all the Schiff base compounds has been checked using their physical constants
and spectral data. The UV λmax (nm), IR νC=N (cm-1), NMR δ (ppm) of CH=N and C=N spectral data
have been correlated with Hammett substituent constants and Swain-Lupton’s parameters using single
and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents
on the above spectral data has been studied. The single parameter correlation with few Hammett
constants and Swain-Lupton’s parameters gave satisfactory correlation coefficients whereas all
multiple correlations gave satisfactory correlation coefficients with Inductive, Resonance, Field and
Swain-Lupton’s parameters. The antimicrobial activities of all the Schiff bases have been studied
using standard methods.
References
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