Synthesis and spectral Hammett correlation analysis of some (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-one compounds

ABSTRACT

A series of substituted of (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-one compounds by cross-aldol condensation reaction of 5-bromothiophene-2-carbaldehyde with various substituted acetaldehyde in the presence sodium hydroxide (base). The synthesized substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-one compounds was characterized by physical constants, UV, FT-IR, ¹H & ¹³C-NMR spectral data. The group frequencies of infrared ʋ(cm^-1) of CO s-cis and s-trans, CH in-plane and out of plane, CH=CH out of plane, >C=C< out of plane modes, NMR chemical shifts δ (ppm) of H_α, H_β, CO, C_α and C_β of these chalcones were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analyses.