ABSTRACT
This study investigated the qualitative phytochemical compositions of Jatropha tanjorensis and evaluated the efficacies of the ethanol leaf extracts of the plant on carbon tetrachloride (CCl4) induced liver fibrosis in female albino rats. Female rats were obtained from Zoology Department animal house, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria and they were distributed into 5 groups. Each group has 4 rats. The average weights of the rats in each group was taken and recorded at three days interval and the rats were fed with poultry grower mash and monitored for some period of time. The rats were given CCl4 to cause fibrosis. Later different dosages of ethanol extracts of J. tanjorensis were given to them as treatments for the ailment. Also, the phytochemical analysis of the plant was carried out. The results of the histoarchitecture of the liver showed that the portal triad and the hepatocyte in the normal and untreated group revealed normal arrangement of hepatocyte and clear portal vein. While the CCl4 induced group without treatments, revealed shrunken portal area and congested portal vein. The rats with 100 mg /kg body weight and 200 g/kg body weight treated plus CCl4 induced group revealed normal liver cells with mild congestion of portal vein than the one treated with 50 g/kg. However, the use of 200 mg/kg of leaf extract of .J tanjorensis is more effective for the management of liver fibrosis than the other dosages as revealed in the research work. The results of the phytochemical screening revealed the presence of saponins, Tepenoids, Alkaloids, phenolics, Tannins, Flavonoids and Cardiac glycosides. Phytobatannins and Steroids were absent
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