ABSTRACT
A Series of tetrahydropyrimidine has been derived by LaCl3·7H2O catalysed one pot three
component biginelli reaction. The compounds have synthesised from an aldehyde, ethyl acetoacetate
and urea or thiourea in an ethanolic medium using a catalytic amount of (LaCl3·7H2O). This method
provides quantitative yield and the catalysis can be easily recovered from the reaction medium and be
re-used.
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