Nowadays, nitrogenous heterocyclic molecules are attracting a great deal of attention among medicinal chemists. In this group of potential heterocyclic drugs, benzimidazole scaffolds appear to be predominant. In recent years, benzimidazole compounds have emerged as a hot research topic due to their varied biological activities. Several benzimidazole derivatives have been synthesized in the last decades, and many of these compounds exhibited excellent bioactivity against many ailments, as well as remarkable bioavailability, safety, and stability profiles. In this research article we explored an efficient protocol for the synthesis of benzimidazole containing benzoxazole derivative from aldehydes, and benzo[d]imidazol derivative using acetic acid as a solvent at ambient temperature is described. Compared with other methods, this new method has the advantages of easier work-up, clean reaction conditions, high yields, and an environmentally benign procedure.
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