The purpose of this study was to distinguish histopathological changes in carp fish (Carassius auratus) infected by Aeromonas hydrophila with different densities. Five treatments were used in the survey for this research method. The treatments used were bacterial infusion of A. hydrophila in the test fish through intramuscular injection with various densities, namely: A. without infection, B: 105 CFU/mL, C: 106 CFU/mL, D: 107 CFU/mL, and E: 108 CFU/mL. The parameters observed were histopathological changes in gill organs, kidneys and hearts of carp fish (gold fish). Data from histopathological observations were analyzed descriptively. The results present gill organs, liver and kidneys of carp fish infected with the bacteria A. hydrophila at various densities experiencing histopathological changes in the form of hemorrhages, necrosis and congestion and hyperplasia of the renal tubules. Other changes that occur were in the kidney organ experiencing a melanomacrophage center (MC). Tubules were coated with connective tissue and lymphocyte infiltration. The most severe organ damage that occurs in carp fish infected with the bacteria A. hydrophila at a density of 108 CFU/mL (treatment E) is shown by a low survival of 5%.
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