Thespesia populnea Corr. floral extract has been shown to have anti-steroidogenic effect. Bark extract of Thespesia populnea has no toxicity as per the earlier reports of traditional medicine used by the tribal peoples of Indira Gandhi Wild Life Sanctuary, Pollachi, South India. In the present study, anti-steroidogenic effect of Thespesia populnea (Malvacea) bark was evaluated in adult female mice (Mus musculus). Methanolic extract of Thespesia populnea bark (METP) was administered orally at the doses of 100, 250, 400 mg/kg body weight for a duration of 30 days, and normal saline (0.9%) to control group. There was significant reduction in the (P<0.05) wet weight of both ovaries. Cholesterol content in ovaries of METP treated mice was significantly increased (P<0.05). The two ovarian enzymes 3-,17-hydroxy steroid dehydrogenase and serum estrogen and progesterone also decreased (P<0.05) significantly. Administration of METP in mice did not show any variation in the hematological and bio-chemical parameters. A certain number of adult female mice were ovariectomized (OVX) and tested for hormone levels with EDP and with EDP + Extract to confirm the antifertility effect of METP. It is concluded that antifertility effect of METP could be due to its anti-steroidogenic activity.
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