ABSTRACT
The new series of sulphonamide schiff base compounds obtained from sulfa drugs has been synthesized by the reaction of 4,4′-Diaminodiphenyl sulfone with aldehydes. The synthesized compounds were characterized by using FT-IR, Mass spectroscopy to confirm the chemical structures of synthesized compounds. The sulfonamide Schiff base compounds were tested for anti-bacterial, anti-fungal and anti-malarial. The biological activity of synthesized compounds was evaluated by assessing the inhibitory concentration by measuring their inhibition zone versus certain kinds of standard antibiotics. Noticeably, compound 4a, 5b, 5c was the most potent compound in vitro anti-microbial with compare to reference drug. In addition, two compounds exhibited liquid crystalline property.
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