ABSTRACT
A new series of pyrimidine-5-carbonitrile derivatives has been prepared by condensation of different aryl amines with 1-ethyl-2-(ethylthio)-4-(4-fluorophenyl)-1,6-dihydro-6-oxopyrimidine-5-carbonitrile (2). The key starting compound 6-(4-fluorophenyl)-1,2,3,4-tetrahydro-4-oxo-2-thioxopyrimidine-5-carbonitriles undergo electrophilic substitution with ethyl iodide and give di alkylated compound (2). Compound (2) undergo nucleophilic substitution reaction with amine to give their corresponding derivatives (3). The synthesized compounds were characterized by IR, 1H NMR and mass spectra.
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