Oxidative stress occurs as a result of an imbalance between production of reactive oxygen species and the regulatory mechanism produced by human cells. The stress contributes to the pathogenesis of inflammatory diseases. Synthetic antioxidants like butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and ascorbic acid, are used in curtailing the menace of the stress. Their potential depends on the type of phytochemicals in the oil. It is on this basis this study aimed at isolating, characterizing and investigating antioxidant potential of rind essential oil of C. reticulata. To achieve this aim, 500g of fresh rinds of C. reticulata were pulverized and hydro-distilled for three hours. GC and GC-MS analysis of the oil revealed the abundance of hydrocarbon monoterpenoids (96%). The most abundant compounds in the oil were D-limonene (82.4%), γ-Terpinene (9.4%) and β-Myrcene (2.2%). The oil exhibited antioxidant activity, with IC50value (10.73μl/ml), which was lower to the activity of ascorbic acid (49.14μl/ml). This shows that the oil is more active than ascorbic acid. Hence, the oil could be explored for the treatment of oxidative stress.
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