Diabetes mellitus is a complex metabolic disorder resulting from either insulin insufficiency or insulin dysfunction. Diabetes mellitus affects most of the people in both developed and developing countries. The treatment of diabetes with synthetic drugs is costly and chances of side effects are high. Phytomedicine has been used since ancient times in various parts of the world where access to modern medicine is limited. Present study was designed to check the anti-diabetic activity of methanolic extract of Engelhardtia colebrookiana L. locally known as samma or samna on Alloxan induced diabetic rabbits. Animals were divided into five groups. Group I: In this group rabbits were considered as normal control. Group II: In this group rabbits was considered as diabetic control. Group III: In this group rabbits were given by Glucophage. Group IV: In this group rabbits were given by oral dose of 1g of methanolic extract of Engelhardtia colebrookiana’s bark per day. Group V: In this group rabbits were given oral dose of 1g of methanolic extract of Engelhardtia colebrookiana’s leaves per day. The leaves extract significantly reduces the blood glucose level and body weight along with these it was found very effective in improving serum insulin level as compared to other groups and no side effect was observed in the rabbits during treatment.
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