Emerging of dengue infection has increased dramatically in Sri Lanka in recent years. Initial infection with a particular serotype is known as primary infection which is usually asymptomatic or mild disease manifestations. Although cross reactive T cells and cross reactive antibodies have been shown to contribute to disease pathogenesis, these mechanisms alone do not explain the immune – pathological mechanisms leading to severe infection. However, this study has suggested that antigen antibody detection and viral RNA detection in host blood contribute to the occurrence of disease. Therefore, it is important to further investigate the quality of dengue specific immune responses and confirmation of dengue RNA content in patients with acute severe dengue and asymptomatic dengue infection.
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