ABSTRACT
Bisphenol A (BPA) is a high-production volume chemical widely used as a monomer in plastics and known for its endocrine-disrupting properties. Exposure to BPA has been associated with obesity and other metabolic disorders through its effects on lipid metabolism, adipogenesis, and hormonal regulation. Medicinal plants with proven pharmacological activities are being explored as safer alternatives for managing such conditions. Alchornea cordifolia, a plant commonly used in African ethnomedicine, has been reported to possess antioxidant, anti-inflammatory, and anti-diabetic properties. This study investigated the effect of the ethanolic extract of A. cordifolia on adipose tissue weight, liver weight, lipid profile, lipase activity, and HMG-CoA reductase activity in BPA-induced obese Wistar rats. Obesity was induced by administering BPA (50 µg/ml), followed by treatment with graded doses of A. cordifolia extract. The results showed that BPA administration significantly increased adipose tissue and liver weights, as well as altered lipid profiles in young male Wistar rats. Treatment with A. Cordifolia extract significantly reduced these changes, demonstrating anti-hypercholesterolemic and antihyperlipidemic effects. Among the tested doses, 1000 mg/kg of the ethanolic extract exhibited the greatest efficacy in mitigating BPA-induced obesity.
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