ABSTRACT
Monosodium glutamate (MSG) is one of the commonly used food-additives in commercial foods and it is known to be responsible for various human disorders. We evaluated the effect of low and high doses of monosodium glutamate (MSG) on oxidative stress in both female and male rats, and its pathological role in various cancer types. A total of 120 wistar rats (60 female and 60 male) were used for this. The rats were divided equally into 3 groups (40 rats each) representing the various experimental durations (2, 4, and 6 months). Each of these groups were further divided equally into 8 subgroups containing 5 rats each, labeled as follows: female rats orally administered daily 1000, 2000, 3000 mg/kg body weight MSG representing low (LD), medium (MD) and high (HD) dose of MSG respectively while the control group was fed normal rat chow and water; also, the male rats were given the same treatments. The superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were significantly decreased and the MDA levels increased in the male and female rats by the doses of MSG following short term and long term administration. Furthermore, the markers of pancreatic cancer (CA-19-9), colorectal cancer (CEA), ovarian cancer (CA-125) and prostate cancer (PSA) were significantly increased after administration of the various doses of MSG in the rats. All the doses of MSG negatively compromised the antioxidant defence system in both genders and enhanced the progression of colorectal, pancreatic, prostate and ovarian cancers without gender disparity. Although MSG offers enormous benefits to the food industry, continuous use of this food additive can have detrimental effects on human health. Thus, the use of MSG in foods should be mitigated or if possible not used at all.
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