ABSTRACT
Indoneesiella echioides (L.) Nees is a well-known herb used in ethnomedicine. Flavonoids and alkaloids are major constituents of Indoneesiella echioides (L.) Nees. In this study, we investigated the anticancer activity of KB and normal HGF-1 cells. We demonstrated the effects of ethanolic extract of Indoneesiella echioides (L.) Nees on the cell growth and apoptosis in KB and normal HGF-1 cells were analyzed by the generation of reactive oxygen species (ROS), the level of mitochondrial membrane potential (∆ψM) and apoptotic morphological changes were analyzed by AO/EtBr, AO and Hoechst staining. Our results indicated that the ethanolic extracts of Indoneesiella echioides (L.) Nees shows better anticancer activity through it’s induces increased cell death, ROS generation, alteration of mitochondria membrane potential and apoptosis
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