**ABSTRACT**

The research objectives are: 1) to analyze several parameters of the aquatic environment that affect the lead accumulation in shellfish body (*Anadara granosa* (Linnaeus, 1758)) at eastern coastal waters of Muara Gembong sub-district by using multiple regression analysis, 2) to reduce the variables through principal component analysis to reduce the research cost for monitoring of lead pollution in the next time, and 3) to analyze the location which has similar characteristics of lead accumulation by using hierarchical cluster analysis. Based on the multiple regression analysis, the lead concentration in water, lead concentration in sediment, and sulfur concentration in sediment has a very significant correlation (P < 0.01) to the lead accumulation in shellfish body. In contrast, COD of waters has a significant correlation (P < 0.05), which correlation coefficient (R) is 0.97. Through the principal component analysis, the lead concentration in sediment, COD of waters, and sulfur concentration in sediment gives the most variance contribution to the total data variance. Therefore, those variables are sufficiently used to monitor lead pollution on shellfish at the Muara Gembong sub-district’s coastal waters. Cluster analysis shows that the location is agglomerated to be 3 clusters, which coastal water of Southern Bahagia Beach and Western Mekar Beach has highly similar lead accumulation characteristics.

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