The present research work discusses the simple, specific and economical UV Spectrophotometric method has been developed using acetonitrile-water (80:20v/v) as a diluent to estimate elagolix sodium content in bulk and pharmaceutical dosage formulation. Spectrophotometric method has been developed for the estimation of elagolix sodium in Tablet dosage form. The maximum wavelength λmax was found to be 274.5 nm. A recovery percentage of elagolix sodium in tablet formulation was observed in the range of (98.85-100.72%). Beers law was obeyed in the concentration range of 12-48 μg/ml. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y = 24.851x – 0.0232 with (R2 = 0.9979). The LOD and LOQ are 0.00133 μg/ml and 0.00403 μg/ml respectively. Validation was performed Linearity, specificity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 48 hours.
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