Substituted Camphor-Hydrazide Schiff Bases: Synthesis, Characterization, and Anticancer Activity

ABSTRACT

The present study covers synthesis of 2-phenylacetohydrazide linked camphor Schiff base. Very few studies have been conducted on synthesis of camphor derivatives, highlighting the significance of my research in this area. For this research, 2-phenylacetic acid converted into their ester form, ethyl 2-phenylacetate using ethanol. Further, reaction with hydrazine hydrate forms the 2-phenylacetohydrazide. At final step, reaction with camphor yields (E)-2-phenyl-N‘-(1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)acetohydrazide. Structure identification is verified by IR spectroscopy, mass spectroscopy, elemental analysis, ¹H and ¹³C NMR. All the compounds were evaluated for anticancer activity against the MCF-7 breast cancer cell line, showing cytotoxicity in the range of 10 mg/ml to 40 mg/ml and MBL-104 exhibited the highest cytotoxic potency. These results open the door for further detailed applications in medicinal chemistry.

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WSN 206 (2025) 17-29

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