Synthesis, Characterization, and Biological Evaluation of Cu(II) Mixed-Ligand Complexes as Potent Antimicrobial Agents

ABSTRACT

Six mixed-ligand complexes of Cu(II) were synthesized with quinazolinone Schiff bases (B₁-B₆) and 2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one (A), and fully characterized. Their structural attributes were examined through elemental analysis, infrared (IR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy, fast atom bombardment mass spectrometry (FAB-MS), magnetic measurement, and thermal analysis. Additionally, the biological activities of the ligands, complexes, and metal salt were evaluated against microorganisms and compared with standard drugs. The results demonstrated that the newly formed metal complexes displayed significantly elevated biological activities in contrast to the free ligands and metal salt. These findings imply the potential of these mixed-ligand complexes for further advancement as antimicrobial agents.

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WSN 192 (2024) 188-203

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