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Home 2018

Synthesis and antimicrobial evolution of some new benzotriazole substituted 1,3,4-thiadiazoles

Authors: Dinesh R. Godhani, Vishal B. Mulani, Jignasu P. Mehta, Nipul B. Kukadiya, 100 (2018) 51-60

2024-02-14
Reading Time: 3 mins read
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ABSTRACT

A series of novel benzotriazole-substituted 1,3,4-thiadiazole-2(3H)-thione derivatives was synthesized by cyclization of Schiff base. The structures were recognized on the foundation of spectral tools and their purity by elemental analysis. All the compounds were preliminary evaluated for their in vitro antimicrobial activities against five bacterial strains viz [Staphylococcus aureus (MRSA; ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922), Acinetobacter baumannii (ATCC 19606), Pseudomonas aeruginosa (ATCC 27853)] and two fungi Strains viz. [Candida albicans (ATCC 90028), Cryptococcus neoformans (ATCC 208821)]. Several compounds exhibited remarkable antimicrobial activity, out of 15 compounds, three compounds viz. 5a, 5g and 5i showed promising antifungal activities with no signs of human cells cytotoxic [HEK293: Human Embryonic Kidney cells (ATCC CRL-1573)] and haemolytic activity [Whole blood (ARCBS 5400 00150)].

 

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Tags: Antimicrobial activitybenzotriazoleCytotoxicityhaemolysisSchiff basethiadiazole
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