One Pot Synthesis and Antimicrobial Screening of 2-Amino-3-Cyanopyridine derivatives of Vanillin Analogues

ABSTRACT

A number of 2-Amino-6-(aryl)-4-[4-(2,4-dichlorophenylmethoxy)-3-methoxyphenyl]-3-cyanopyridine (2a-2j) derivatives have been synthesized by refluxing of previously synthesized 3-Methoxy-4-(2, 4-dichlorophenylmethoxy) chalcone (1a-1j) with malononitrile and ammonium acetate. The physical and analytical data of all the synthesized derivatives (2a-2j) were collected and reported. The structures of all newly synthesized 2-amino-3-cyanopyridine derivatives has been characterized by different analytical techniques like Elemental analysis, Infrared spectroscopy, ¹H NMR and ¹³C NMR spectroscopy and Mass spectroscopy. Furthermore, each synthesized compounds were screened for its in-vitro antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal towards fungi Aspergillus niger (A. niger) and Candida albicans (C. albicans) with the concentration of 40 μg/ml and data was collected and analyzed.

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