ABSTRACT
Trachoma is a Neglected Tropical Disease (NTD) and one of the most common ocular contagious diseases, caused by different serovers such as A, B, Ba ,C of bacterium Chlamydia trachomatis that occurs recurrently. Most infants are adversely affected from chronic keratoconjunctivitis, leading to blindness in later life. Epidemiological studies in 2023 revealed that approximately 115.7 million people were at risk of trachoma, but presently it has been declined to almost 103.2 million. Basically this disease is predominant in least developed or developing nations with high poverty. Preventive measures being implemented by the World Health Organization (WHO) , popularly known as ‘SAFE’ strategy: S for surgery, A for antibiotic dissemination, F for facial cleanliness, and E for environmental improvements. Now-a-days it is effectively and extensively applied; that’s why number of active patients are reduced drastically, but trachoma-free world creation should be the principal and researches will make it possible.
References
- [1] WHO (2022) Trachoma, factsheet. World Health Organization ,Geneva.
- [2] WHO (2024) WHO Alliance for the Global Elimination of Trachoma: progress report on elimination of trachoma,2023. Weekly epidemiological record 99(28), 363-380.
- [3] Gitsels A, Sanders N and Vanrompay D (2019) . Chlamydial infection from outside to inside. Microbiol. 10 ,2329.
- [4] El-Asrar AM, Van den Oord JJ, Geboes K, Missotten L, Emarah MH and Desmet V(1989). Immunopathology of trachomatous conjunctivitis. Br J Ophthalmol. 73 (4), 276-282.
- [5] Thylefors B, Dawson CR, Jones BR, West SK and Taylor HR (1987). A simple system for the assessment of trachoma and its complications. Bull World Health Organ. 65 ,477-483.
- [6] Burton MJ and Mabey DC (2009). The global burden of trachoma: a review. PLoS Neglected Tropical Diseases 3,
- [7] Rottenberg ME, Gigliotti-Rothfuchs A and Wigzell H (2002). The role of IFN-gamma in the outcome of chlamydial infection. Curr Opin Immunol. 14,444-451.
- [8] Grassly NC, Ward ME, Ferris S, Mabey DC and Bailey RL (2008). The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. PLoS Neglected Tropical Diseases 2 ,e341.
- [9] West SK, Munoz B, Mkocha H, Hsieh YH and Lynch MC (2001) . Progression of active trachoma to scarring in a cohort of Tanzanian children. Ophthalmic Epidemiol. 8 ,137-144.
- Natividad A, Hanchard N, Holland M J, Mahdi O S M, Diakite M, Rockett K, Jallow O ,Joof H M, Kwiatkowski D P, Mabey D C and Bailey R L (2007). Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians. Genes Immun. 8 (4), 288-295.
- Miller K, Schmidt G, Melese M, Alemayehu W, Yi E, Cevallos V, Donnellan C, Olinger L, Fantaye D, Gaynor B, Whitcher JP and Lietman T(2004b). How reliable is the clinical exam in detecting ocular chlamydial infection? Ophthalmic Epidemiol. 11(3), 255-262.
- Wright HR, Turner A and Taylor HR (2008) . Trachoma. Lancet 371, 1945-1954.
- Lee S, Alemayehu W, Melese M, Lakew T, Lee D, Yi E, Cevallos V, Donnellan C, Zhou Z, Chidambaram JD, Gaynor B, Whitcher JP and Lietman T(2007). Chlamydia on children and flies after mass antibiotic treatment for trachoma. J. Trop. Med. Hyg. 76 (1), 129-131.
- Emerson P, Lindsay SW, Alexander N, Bah M, Dibba SM, Faal HB, Lowe KO, McAdam K P W, Ratcliffe AA, Walraven G E L and Bailey RL (2004). Role of flies and provision of latrines in trachoma control: cluster-randomized controlled trial. Lancet 363 , 1093-1098.
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