Characterization of mixed ligand Cu(II) complexes through mass spectral, thermal and biological studies

ABSTRACT

A series of six mixed-ligand complexes of Cu(II) with 7-hydroxy-4-methoxy-10,11-dihydroindeno[5,4-c]chromene-6(9H)-one (A) and Schiff bases derived from quinazolinone (Qn1-Qn6) were synthesized and fully characterized. The structural features of the complexes were investigated using various spectroscopic techniques, including elemental analysis, infrared (IR) and proton nuclear magnetic resonance (¹H-NMR) spectroscopy, fast atom bombardment mass spectrometry (FAB-MS), magnetic measurement, and thermal studies. Furthermore, the biological activities of the ligands, complexes, and metal salt were assessed in vitro against both gram-positive and gram-negative microorganisms. The results showed that the newly synthesized metal complexes exhibited significantly higher biological activities compared to the free ligands and metal salt. These findings suggest that the mixed-ligand complexes have potential for further development as antimicrobial agents.

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WSN 182 (2023) 156-178

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