https://doi.org/10.65770/EOXS8434
ABSTRACT
In an effort to develop biologically active molecules, a series of novel thieno[2,3-d]pyrimidine derivatives tethered with 2-chloroquinoline-3-carbaldehyde through an amino linkage were synthesized and characterized using appropriate spectroscopic techniques. The synthetic methodology exhibited several notable advantages, including a reduced number of reaction steps, high product yields, mild reaction conditions, and elimination of additional purification procedures. The synthesized compounds were screened for their in vitro antimicrobial activity against selected microbial strains. Biological evaluation revealed that several derivatives displayed moderate to good antimicrobial potency, indicating the potential of these heterocyclic scaffolds as good antimicrobial agents
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