ABSTRACT
A new set of hybrids containing triazine nucleus incorporated with benzomidazole moiety has been produced by reacting 2-(1-(4,6-dichloro-1,3,5-triazin-2-yl)piperidin-4-yl)-1H-benzo[d]imidazole with substituted anilines in the presence of 1,4-dioaxane as a solvent by a novel stepwise synthetic approach. The reaction was observed using thin-layer chromatography; the freshly synthesized compounds were purified using column chromatography and were structurally confirmed using IR, mass spectrometry and 1H NMR spectroscopy.
References
- [1] Singla, P., Luxami, V., & Paul, K. (2015). Triazine–benzimidazole hybrids: Anticancer activity, DNA interaction and dihydrofolate reductase inhibitors. Bioorganic & medicinal chemistry, 23(8), 1691-1700.
- [2] Zhang, K., Tian, S., Wang, X., Li, B., Pang, J., Xu, J., & Xing, J. (2025). Functional group boosting triazine ring-opening for low-temperature synthesis of heptazine-based graphitic carbon nitride. Green Chemistry, 27(15), 3863-3868.
- [3] Ricciotti, L., Roviello, G., Tarallo, O., Borbone, F., Ferone, C., Colangelo, F., … & Cioffi, R. (2013). Synthesis and characterizations of melamine-based epoxy resins. International journal of molecular sciences, 14(9), 18200-18214.
- [4] Veloso, A. J., Hung, V. W., Cheng, X. R., & Kerman, K. (2012). Analysis of Amyloid Beta Aggregation Kinetics Using Sym‐Triazine β‐Sheet Inhibitors. Electroanalysis, 24(9), 1847-1851.
- [5] Makowska, A., Sączewski, F., Bednarski, P. J., Sączewski, J., & Balewski, Ł. (2018). Hybrid molecules composed of 2, 4-diamino-1, 3, 5-triazines and 2-imino-coumarins and coumarins. Synthesis and cytotoxic properties. Molecules, 23(7), 1616.
- [6] Singh, S., Utreja, D., & Kumar, V. (2022). Pyrrolo [2, 1-f][1, 2, 4] triazine: a promising fused heterocycle to target kinases in cancer therapy. Medicinal Chemistry Research, 1-25.
- [7] Wróbel, A., Kolesińska, B., Frączyk, J., Kamiński, Z. J., Tankiewicz-Kwedlo, A., Hermanowicz, J. & Drozdowska, D. (2020). Synthesis and cellular effects of novel 1, 3, 5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines. Investigational New Drugs, 38, 990-1002.
- [8] Lim, H. Y., Tan, Y. S., Yeo, C. I., & Dolzhenko, A. V. (2025). A new one-pot microwave-assisted synthesis and structural analysis of 6, N2, N4-trisubstituted 1, 3, 5-triazine-2, 4-diamines. Journal of Molecular Structure, 1325, 140965.
- [9] Massoomi, F., Savage, J., & Destache, C. J. (1993). Omeprazole: a comprehensive review. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 13(1), 46-59.
- [10] Adams, M. H., Ostrosky, J. D., & Kirkwood, C. F. (1988). Therapeutic evaluation of omeprazole. Clinical pharmacy, 7(10), 725-745.
- [11] Kanwal, A., Ahmad, M., Aslam, S., Naqvi, S. A. R., & Saif, M. J. (2019). Recent advances in antiviral benzimidazole derivatives: a mini review. Pharmaceutical Chemistry Journal, 53, 179-187.
- [12] Nimesh, H., Sur, S., Sinha, D., Yadav, P., Anand, P., Bajaj, P., … & Tandon, V. (2014). Synthesis and biological evaluation of novel bisbenzimidazoles as Escherichia coli topoisomerase IA inhibitors and potential antibacterial agents. Journal of Medicinal Chemistry, 57(12), 5238-5257.
Download all article in PDF
![]()



