ABSTRACT
Ionizing radiation exposure induces severe cellular injuries, such as single- and double- strand breaks, base lost, base’s changes, chromosomal aberrations, etc. Double strand breaks are the most significant and dangerous for the cell. As a result of action of the ionizing radiation the level of free radicals (more specific reactive oxygen species) increases many times and leads to severe cellular injuries. Oxidative stress has appeared. Double strand breaks could lead to formation of genomic instability that could become a stable change and to mutate the cell. High doses of ionizing radiation led to destroying of the whole DNA-genome and to formation of DNA-fragmentation. The aim of the currents study is to qualitatively determine the possible radioprotective ability of the amino acids N-acetyl-L-cysteine and N,N,N-trimethyl glycine (betaine). DNA-ladders method has been used for conformation of the radioprotective activity of analyzed two amino acids (betaine and N-acetyl-L-cysteine). The obtained result of the conducted research showed a possible high potential for radioprotective ability of both metabolites and set the stage for additional studies in an experimental cell model to confirm or reject the result.
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